Iridium(Ⅲ) complex-based phosphorescent and electrochemiluminescent dual sensor for selective detection of glutathione

• Iridium complex-based phosphorescent and electrochemiluminescent dual sensors enabled selective detection of GSH. Reduction pdo to phen(OH) 2 upon reaction with GSH triggered PL turn-on ECL turn-off response. Sensing mechanisms were elucidated by DFT calculations cyclic voltammetry. Sensor 1 was applied determination concentrations in human serum. Glutathione (GSH) is the most abundant biological thiol involved antioxidant defense systems cells. Lack increases risk oxidative stress, resulting progression cancer. Therefore, a method for highly required. Herein, we report ( 1-3 ) based on iridium complexes These have 1,10-phenanthroline-5,6-dione (pdo) ancillary ligand as common site moiety 1,10-phenanthroline-5,6-diol (phen(OH) fluorescence response electrochemiluminescence high selectivity successfully serum samples methods.